Monday, January 29, 2024

Possible mechaniism for the reversal of dementia. revealed in bird brain!


Black-capped chickadee grows brain cells to remember where it stashed its food!




https://www.ndtv.com/science/popular-bird-species-grows-brain-tissues-to-survive-brutal-winter-3676917#:~:text=According%20to%20National%20Library%20of%20Medicine%20%28NLM%29%20of,winter%20as%20does%20the%20rate%20of%20hippocampal%20neurogenesis.

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830249/



Environmenta! cues/stimuli (e.g. shortening daylight) activate a genetic program wch triggers a biochemiical chain of reactions culminating in the activation of dormant stem cells in. the hippocampus.
"Brain-derived Neurotropic factor" stimulates cell growth in hippocampus --(-the structure of the brain that encodes and stores experience into memories) resulting in a 30% increase in the size of the hippocampus!
If the sequence of. molecular events underlying this process can be understood, it may be similarly activated in the brains of persons with dementia where the hippocampus has atrophied and memory creation and retrieval have been compromised! ...thereby reversing memory and cognitive impairment


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 The Brain Feed

A landmark study from Karolinska Institutet in Sweden has confirmed that adults continue to generate new neurons in the hippocampus, the brain’s memory and learning hub.        Remarkably, neurogenesis was observed across a wide age range, even in individuals up to 78 years old. This discovery challenges long-held beliefs that brain cell growth ceases in adulthood and instead highlights the brain’s lifelong plasticity. The finding has profound implications for developing treatments for memory decline, mood disorders, and neurodegenerative conditions such as Alzheimer’s. 

By proving that the brain can renew itself, researchers have unlocked new hope for therapies that could enhance cognition and resilience at any age.